Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations

Shucai Li, Wenwen Wang, Huan Tang, Kai Chen, Jianhong Yang, Linhong He, Haoyu Ye, Aihua Peng, Lijuan Chen

Index: J. Chromatogr. A. 1344 , 51-8, (2014)

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Abstract

• Impurity separation of honokiol and quercetin by both preparative HPLC and CCC. • Several performance parameters of separation were compared. • CCC provided larger sample loading, especially for a sample with poor solubility. • Six impurities of honokiol including one new compound were isolated.