Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
Fátima M F Vergara, Maria das G M O Henriques, André L P Candea, Jim L Wardell, Marcus V N De Souza
Index: Bioorg. Med. Chem. Lett. 19 , 4937-8, (2009)
Full Text: HTML
Abstract
A series of 11 alpha,omega-diaminoalkanes, (H(2)N(CH(2))(n)NH(2), n=2-12) have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Compounds, (H(2)N(CH(2))(n)NH(2), n=9-12), exhibited a very good activities in the range 2.50-3.12 microg/mL, which can be compared with that of the first line drug, ethambutol (3.12 microg/mL). These results and a preliminary QSAR study can be considered an important start point for the rational design of new leads for anti-TB compounds.
Related Compounds
Related Articles:
The biocompatibility of degradable magnesium interference screws: an experimental study with sheep.
2015-01-01
[Biomed Res. Int. 2015 , 943603, (2015)]
Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.
2015-08-01
[Pharm. Res. 32 , 2625-35, (2015)]
2015-01-01
[PLoS ONE 10 , e0134768, (2015)]
2014-08-21
[World J. Gastroenterol. 20(31) , 10876-85, (2014)]
Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles.
2015-01-01
[AAPS J. 17(1) , 256-67, (2015)]