Biochemical and Biophysical Research Communications 2011-11-04

Intracellular l-arginine concentration does not determine NO production in endothelial cells: Implications on the “l-arginine paradox”

Soyoung Shin, Srinidi Mohan, Ho-Leung Fung

Index: Biochem. Biophys. Res. Commun. 414 , 660-663, (2011)

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Abstract

Highlights ► Our findings provide a possible solution to the “l-arginine paradox”. ► Extracellular l-arginine concentration is the major determinant of NO production. ► Cellular l-arginine action is limited by cellular ARG transport, not the Km of NOS. ► We explain how l-arginine supplementation can work to increase endothelial function.