Diaspirin cross-linked hemoglobin solution as a resuscitative fluid following severe hemorrhage in the rat.
D Malcolm, D Kissinger, M Garrioch
Index: Biomater. Artif. Cells Immobilization Biotechnol. 20(2-4) , 495-7, (1992)
Full Text: HTML
Abstract
The effect of diaspirin cross-linked hemoglobin (DCLHb) on mean arterial pressure (MAP) and heart rate (HR) was compared to Ringer's lactate (RL) and shed blood in a 70% lethal model of hemorrhage (35 cc/kg blood loss) in conscious rats. All animals resuscitated with DCLHb regardless of dose (17.5 and 35 cc/kg) and concentration (7% and 10% solution) exhibited complete restoration of MAP and HR which was maintained for at least 5 hrs. Hemodynamic responses in DCLHb-treated animals were not significantly different from 35 cc/kg blood-treated animals. In RL (105 cc/kg) treated animals the MAP was restored to 60-70% of baseline. 24 hr survival in animals resuscitated with fluids ranged between 88-100% and was not significantly different between treatment groups.
Related Compounds
Related Articles:
A proposed consent process in studies that use an exception to informed consent.
1999-12-01
[Acad. Emerg. Med. 6(12) , 1283-91, (1999)]
1995-01-01
[Artif. Cells Blood Substit. Immobil. Biotechnol. 23(4) , 487-94, (1995)]
Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin
2008-01-01
[Free Radic. Biol. Med. 45(5) , 659-66, (2008)]
Effects of diasprin cross-linked hemoglobin (DCLHb) on cardiac function and ECG in the swine.
1992-01-01
[Biomater. Artif. Cells Immobilization Biotechnol. 20(2-4) , 683-7, (1992)]
2006-07-01
[Anal. Chem. 78(13) , 4634-41, (2006)]