Iron-catalysed Negishi coupling of benzyl halides and phosphates

RB Bedford, M Huwe, MC Wilkinson

Index: Bedford, Robin B.; Huwe, Michael; Wilkinson, Mark C. Chemical Communications, 2009 , # 5 p. 600 - 602

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Citation Number: 63

Abstract

The diarylmethane motif is commonly found in a range of biologically active compounds 1 and pharmaceuticals. 2 Perhaps the most useful catalytic route to this class of compounds is via transition-metal-catalysed cross-coupling reactions. The copper-catalysed coupling of arylGrignard reagents as the nucleophilic coupling partner is successful, 3 but limited by low functional group tolerance. The use of arylboron-based reagents removes this problem but usually ...