Release of betaine and dexpanthenol from vitamin E modified silicone-hydrogel contact lenses.

Kuan-Hui Hsu, Percy Lazon de la Jara, Amali Ariyavidana, Jason Watling, Brien Holden, Qian Garrett, Anuj Chauhan

Index: Curr. Eye Res. 40(3) , 267-73, (2015)

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Abstract

To develop a contact lens system that will control the release of an osmoprotectant and a moisturizing agent with the aim to reduce symptoms of ocular dryness.Profiles of the release of osmoprotectant betaine and moisturizing agent dexpanthenol from senofilcon A and narafilcon B contact lenses were determined in vitro under sink conditions. Both types of lenses were also infused with vitamin E to increase the duration of drug release due to the formation of the vitamin E diffusion barriers in the lenses. The release profiles from vitamin E-infused lenses were compared with those from the control lenses.Both dexpanthenol and betaine are released from commercial silicone hydrogel lenses for only about 10 min. Vitamin E loadings into contact lenses at about 20-23% can increase the release times to about 10 h, which is about 60 times larger compared to the control unmodified lenses.Vitamin E-loaded silicone hydrogel contact lenses released betaine and dexpanthenol in a controlled fashion.