Selective oxidation of terminal isopropyl groups to tertiary alcohols by electrochemical methodology

S Maki, K Konno, H Takayama

Index: Maki, Shojiro; Konno, Katsuhiro; Takayama, Hiroaki Tetrahedron Letters, 1997 , vol. 38, # 40 p. 7067 - 7070

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Citation Number: 18

Abstract

Selective oxidation of terminal isopropyl groups to the correspoding tertiary alcohols by an electrochemical method is described. Under the conditions using the Tl (TFA) 3- hematoporphyrin-O2-cathodic reduction system, several substrates such as cholesterol (1) and Grundmann's alcohol (3) gave the corresponding tertiary alcohols 2 and 4, respectively, in reasonable yield.