Copper (I)??Mediated Cyanation of Boronic Acids
…, L Zhang, M Hu, J Cheng
Index: Zhang, Guoying; Zhang, Lingli; Hu, Maolin; Cheng, Jiang Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 291 - 294
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Citation Number: 39
Abstract
Abstract A simple cyanation reaction of boronic acids with cuprous cyanide is achieved, providing nitriles in moderate to good yields. In the presence of copper (I) iodide, trimethylsilyl cyanide is also a good cyanating reagent. The reaction can be conducted on a 10-mmol scale. Thus, this new approach represents an exceedingly practical method for the synthesis of nitriles.
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