Antimicrobial Agents and Chemotherapy 2008-04-01

Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance.

Mathieu Hernould, Séverine Gagné, Michel Fournier, Claudine Quentin, Corinne Arpin

Index: Antimicrob. Agents Chemother. 52 , 1559-63, (2008)

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Abstract

Gene inactivation and complementation experiments showed that the tripartite AheABC efflux pump of Aeromonas hydrophila extruded at least 13 substrates, including nine antibiotics. The use of phenylalanine-arginine-beta-naphthylamide (PAbetaN) revealed an additional system(s) contributing to intrinsic resistance. This is the first analysis of the role of multidrug efflux systems in Aeromonas spp.

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