Catalytic Asymmetric Addition of Polyfunctional Dialkylzincs to. beta.-Stannylated and. beta.-Silylated Unsaturated Aldehydes

…, PY Chavant, H Stadtmueller, P Knochel

Index: Ostwald, Roswitha; Chavant, Pierre-Yves; Stadtmueller, Heinz; Knochel, Paul Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4143 - 4153

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Citation Number: 108

Abstract

The enantioselective preparation of scalemic secondary alcohols by the addition of an organometallic to an aldehyde' constitutes the most general preparation of this important class of compounds, besides the asymmetric hydrogenation of unsymmetrical ketones.2 Dialkylzincs have proven to be especially useful reagents for perform- ing the asymmetric addition reaction in the presence of catalytic amounts of a chiral amino The limited availability of ...