Alternative synthesis of tadalafil: PDE5 inhibitor
…, PP Reddy, A Bhattacharya, R Bandichhor
Index: Anumula, Raghupathi Reddy; Madivada, Lokeswara Rao; Gilla, Goverdhan; Raju, V. V. N. K. Prasad; Kagga, Mukkanti; Reddy, Padi Pratap; Bhattacharya, Apurba; Bandichhor, Rakeshwar Synthetic Communications, 2008 , vol. 38, # 23 p. 4265 - 4271
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Citation Number: 2
Abstract
Abstract Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet–Spengeler type reaction and DCC (N, N′-dicyclohexylcarbodiimide)/HOBt (N- hydroxybenzotriazole)–mediated double amidation employing sarcosine ethyl ester hydrochloride.
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