Two concise syntheses of cialis via the N-acyliminium Pictet-Spengler reaction
JD Revell, N Srinivasan, A Ganesan
Index: Revell, Jefferson D.; Srinivasan, Natarajan; Ganesan Synlett, 2004 , # 8 p. 1428 - 1430
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Citation Number: 19
Abstract
Inhibition of the cGMP specific Type V phosphodiesterase (PDE5) was originally investigated as a target for antihypertensive and antianginal therapy. With the serendipitous discovery of the effects of the PDE5 inhibitor sildenafil, such compounds have become a powerful means [1] of treating erectile dysfunction. Besides sildenafil (Viagra, Pfizer), two other PDE5 inhibitors, vardenafil (Levitra, Bayer/GlaxoSmithKline) and tadalafil, (Cialis, Icos/Lilly) have recently gained ...
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