Continuous-flow synthesis of [11C] raclopride, a positron emission tomography radiotracer, on a microfluidic chip

S Haroun, Z Sanei, S Jivan, P Schaffer…

Index: Haroun, Samar; Sanei, Zahra; Jivan, Salma; Schaffer, Paul; Ruth, Thomas J.; Li, Paul C.H. Canadian Journal of Chemistry, 2013 , vol. 91, # 5 p. 326 - 332

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Citation Number: 9

Abstract

11C-labelled radiotracers such as [11C] raclopride are produced in a process that can take between 45 and 60 min to complete. These conventional approaches can consume upwards of 75% of the 11C (t 1/2= 20 min) due to radioactive decay alone, even more if synthesis losses are considered. To compensate, a large starting quantity of radioactive precursors such as [11C] methyl iodide is required to produce an adequate amount of the ...