Tetrahedron letters

Synthesis and characterization of naphthalimide-containing peptide nucleic acid

H Ikeda, Y Nakamura, I Saito

Index: Ikeda, Hisafumi; Nakamura, Yushin; Saito, Isao Tetrahedron Letters, 2002 , vol. 43, # 32 p. 5525 - 5528

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Citation Number: 21

Abstract

Naphthalimide-containing PNA monomer unit 6 was synthesized for the preparation of PNAs containing a naphthalimide chromophore (NPNA). PNA oligomers were purified by reversed- phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses revealed that the PNA oligomer containing a naphthalimide moiety at the amino terminal stabilizes PNA–DNA hybrids.

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Synthesis and characterization of naphthalimide-containing peptide nucleic acid

Abstract

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