2-(trimethylsilyl) ethanethiol in nucleoside chemistry. A short route for preparing thionucleosides and their methyl disulfides
…, I Gautier-Luneau, M Fontecave…
Index: Chambert, Stephane; Gautier-Luneau, Isabelle; Fontecave, Marc; Decout, Jean-Luc Journal of Organic Chemistry, 2000 , vol. 65, # 1 p. 249 - 253
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Citation Number: 39
Abstract
Incorporation of a thiol function in nucleosides, nucleotides, or oligonucleotides has led to a number of analogues possessing interesting biological properties. 1 For example, 2′, 3′- dideoxy-3′-mercaptonucleoside 5′-triphosphates (T, C, A, G) irreversibly stopped DNA chain elongation by AMV and HIV reverse transcriptase, and the corresponding nucleosides display antiviral activities. 2a, b Recently, we have demonstrated that another nucleotide ...
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