Nucleosidyl??O??Methylphosphonates: A Pool of Monomers for Modified Oligonucleotides

…, M Masojídková, I Rosenberg

Index: Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705

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Citation Number: 13

Abstract

An unique set of 5′??O??and 3′??O??phosphonomethyl derivatives of four natural 2′?? deoxyribonucleosides, 1??(2??deoxy?螃漫?D??threo??pentofuranosyl) thymine, 5′??O??and 2′??O?? phosphonomethyl derivatives of 1??(3??deoxy?螃漫?D??erythro??pentofuranosyl) thymine, and 1?? (3??deoxy?螃漫?D??threo??pentofuranosyl) thymine has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected ...