Stereoselective Total Synthesis of Goniothalesdiol A via Chiron Approach

…, R Somaiah, V Harikrishna, BVS Reddy

Index: Yadav, Jhillu S.; Nageshwar Rao, Ragam; Somaiah, Ragam; Harikrishna, Valaboju; Subba Reddy, Basi V. Helvetica Chimica Acta, 2010 , vol. 93, # 7 p. 1362 - 1368

Full Text: HTML

Citation Number: 4

Abstract

Abstract The stereocontrolled synthesis of goniothalesdiol A, a dihydroxylated tetrahydropyran compound, has been accomplished using D-ribose as chiral precursor. The key steps involved are aryl Grignard reaction, stereoselective alkoxy-directed keto reduction, and intramolecular oxy-Michael addition.