Rate constants and equilibrium constants for thiol-disulfide interchange reactions involving oxidized glutathione

RP Szajewski, GM Whitesides

Index: Szajewski, Richard P.; Whitesides, George M. Journal of the American Chemical Society, 1980 , vol. 102, # 6 p. 2011 - 2026

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Citation Number: 338

Abstract

Abstract: The rate of reduction of oxidized glutathione (GSSG) to glutathione (GSH) by thiolate anions (RS-) follows a Brfnsted relation in pK, s of the conjugate thiols (RSH): Pnuc E 0.5. This value is similar to that for reduction of Ellman's re-agent: Pnuc N 0.4-0.5. Analysis of a number of rate and equilibrium data, taken both from this work and from the literature, indicates that rate constants, k, for a range of thiolate-disulfide interchange reactions are ...