Activation of the phase II enzymes for neuroprotection by ginger active constituent 6-dehydrogingerdione in PC12 cells

J Yao, C Ge, D Duan, B Zhang, X Cui…

Index: Zhang, Liangwei; Duan, Dongzhu; Liu, Yaping; Ge, Chunpo; Cui, Xuemei; Sun, Jinyu; Fang, Jianguo Journal of the American Chemical Society, 2014 , vol. 136, # 1 p. 226 - 233

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Citation Number: 13

Abstract

The cellular endogenous antioxidant system plays pivotal roles in counteracting or retarding the pathogenesis of many neurodegenerative diseases. Molecules with the ability to enhance the antioxidant defense thus are promising candidates for neuroprotective drugs. 6- Dehydrogingerdione (6-DG), one of the major components of dietary ginger, has received increasing attention due to its multiple pharmacological activities. However, how this ...