Synthesis and preliminary evaluation of 2-substituted-1, 3-benzoxazole and 3-[(3-substituted) propyl]-1, 3-benzoxazol-2 (3H)-one derivatives as potent anticancer …

…, RV Rao, JS Yadav, JV Rao, VT Cheriyan…

Index: Murty; Ram, Kesur R.; Rao, Rayudu Venkateswara; Yadav; Rao, Janapala Venkateswara; Cheriyan, Vino T.; Anto, Ruby John Medicinal Chemistry Research, 2011 , vol. 20, # 5 p. 576 - 586

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Citation Number: 17

Abstract

Abstract The synthesis and cytotoxic activity studies of a new series of cyclic amine containing benzoxazole and benzoxazolone derivatives are described. The 2-cyclic amine- 1, 3-benzoxazoles 5a–k, 5-chloro-3-(3-chloropropyl)-1, 3-benzoxazol-2 (3 H)-one 8 and 3-[3- (cyclic amino) propyl]-1, 3-benzoxazol-2 (3 H)-ones 9a–f were synthesized. The newly synthesized compounds with the influence of the presence of cyclic amine moiety in the ...