Mimicking enzymatic transaminations: attempts to understand and develop a catalytic asymmetric approach to chiral α-amino acids

S Bachmann, KR Knudsen…

Index: Bachmann, Stephan; Knudsen, Kristian Rahbek; Jorgensen, Karl Anker Organic and Biomolecular Chemistry, 2004 , vol. 2, # 14 p. 2044 - 2049

Full Text: HTML

Citation Number: 35

Abstract

Attempts are made to build a bridge between asymmetric catalysis and enzymatic reactions by mechanistic investigations and the development of a catalytic and enantioselective approach to amination of α-keto esters by primary amines catalyzed by chiral Lewis acids as a model for transamination enzymes. Different Lewis acids can catalyze the half- transamination of α-keto esters using primary amine nitrogen sources such as ...