Synthesis and study of quaternary ammonium derivatives of dl-1-arylamino-2-hydroxy-3-aminopropanes

…, VK Vizas, AP Stankyavichyus, PB Terent'ev

Index: Stankyavichene, L. M. M.; Kutkyavichyus, S. I.; Raizhene, D. I. L.; Vizas, V. K.; Stankyavichyus, A. P.; Terent'ev, P. B. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 6 p. 400 - 404 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 6 p. 686 - 690

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Abstract

We have previously shown that modification of the structure of the amino-group in 8- adrenoblockers affords compounds with high antiarrhythmic properties [5, 6], and the side effects typical of 8-adrenoblockers almost completely disappear. The-most promising compounds, both from the chemical and pharmacological points of view, are quaternary derivatives of inderal. Quaternization of the amino-group in inderal by a variety of ...