Titanocene (III)-catalyzed conversion of N-(epoxyalkyl) anilines into indolines
JP Maciejewski, P Wipf
Index: MacIejewski, John P.; Wipf, Peter Arkivoc, 2011 , vol. 2011, # 6 p. 92 - 119
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Citation Number: 2
Abstract
Abstract Densely substituted indolines and azaindolines can be obtained by the titanocene (III) chloride catalyzed reductive opening of N-(oxiran-2-ylmethyl) anilines. The reaction optimization, substrate scope, and limitations are discussed, and a mechanistic pathway for the epoxideopening rearrangement is proposed. Keywords: Indoline, titanocene dichloride, N-(epoxyalkyl) aniline, radical addition
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