Mechanistic Study of the Manganese-Catalyzed [2+ 2+ 2] Annulation of 1, 3-Dicarbonyl Compounds and Terminal Alkynes

…, K Yamagata, H Tsuji, E Nakamura

Index: Itoh, Yoshimitsu; Tsuji, Hayato; Yamagata, Ken-Ichi; Endo, Kohei; Tanaka, Iku; Nakamura, Masaharu; Nakamura, Eiichi Journal of the American Chemical Society, 2008 , vol. 130, # 50 p. 17161 - 17167

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Citation Number: 38

Abstract

The manganese-catalyzed dehydrative [2+ 2+ 2] annulation reaction of a 1, 3-dicarbonyl compound and a terminal alkyne provides an efficient and regioselective synthesis of a substituted benzene derivative, highlighted by the exclusive formation of ap-terphenyl derivative from an aryl acetylene. The mechanism and the origin of the regioselectivity of the reaction were explored by experiments and density functional theory (DFT) calculations. ...