Tetrahedron letters

An unusual hydroxyl inversion mediated by dast

CSV Houge-Frydrych, IL Pinto

Index: Houge-Frydrych, Catherine S.V.; Pinto, Ivan L. Tetrahedron Letters, 1989 , vol. 30, # 25 p. 3349 - 3350

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Citation Number: 11

Abstract

Cranakalti (1) is a potent smooth muscle relaxant which exerts its activity by opening cellular potassium channels with subsequent hyperpolarisation of the cellular menbrane. a result of this action crunakalim has been shoed to have potential in the treatment of hypertension 1 anrt asthma 2. lSlring the course of studies aimed at introducing a fluorine atan in place of the 3-hydroxyl group in (1) the reaction of (1) with diethylaninosulphur trifluoride (W&ST)