Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans

VA Ashwood, RE Buckingham, F Cassidy…

Index: Ashwood; Buckingham; Cassidy; Evans; Faruk; Hamilton; Nash; Stemp; Willcocks Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2194 - 2201

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Citation Number: 204

Abstract

The synthesis and antihypertensive activity of a series of novel 4-(cyclic amido)-Wl- benzopyrann-3-ols, administered orally to conscious spontaneously hypertensive rats, are described. The effects of lactam ring size, the presence of heteroatoms in the lactam ring, substitution at C (2) and C (3), relative stereochemistry at C (3) and C (4), and aromatic substitution pattern on the blood pressure lowering activity of this series have been ...