Triterpenoid total synthesis. Synthesis and absolute configuration of mispyric acid
Y Imamura, H Takikawa, M Sasaki…
Index: Imamura, Yusuke; Takikawa, Hirosato; Sasaki, Mitsuru; Mori, Kenji Organic and Biomolecular Chemistry, 2004 , vol. 2, # 15 p. 2236 - 2244
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Citation Number: 11
Abstract
The first synthesis of mispyric acid (1), an inhibitor of DNA polymerase β with a novel triterpene skeleton, was achieved by starting from isoprene (2), geraniol (6) and 1, 5- dimethoxy-1, 4-cyclohexadiene (14). The absolute configuration of the naturally occurring 1 was determined as 2S, 4S.
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