Synthesis of (±)-mispyric acid, a triterpene inhibitor of DNA polymerase β isolated from Mischocarpus pyriformis

Y Imamura, H Takikawa, K Mori

Index: Imamura, Yusuke; Takikawa, Hirosato; Mori, Kenji Tetrahedron Letters, 2002 , vol. 43, # 33 p. 5743 - 5746

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Citation Number: 8

Abstract

In 1999, Hecht and co-workers isolated mispyric acid (1), a structurally unique triterpene dicarboxylic acid with a novel skeleton, from stem bark of Australian plant Mischocarpus pyriformis as a DNA polymerase β inhibitor. 1 This structurally unique monocyclic triterpene is presumably derived via a new biogenetic pathway including direct coupling of two farnesyl units. 1 In continuation of our works on synthesis of DNA polymerase inhibitors 2 and biosynthetically unique ...