The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol

S BARNARD, RC Storr, PM O'NEILL…

Index: Journal of Pharmacy and Pharmacology, , vol. 45, # 8 p. 736 - 744

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Citation Number: 19

Abstract

... To investigate further the pharmacology of paracetamol, compounds 2-7 (Fig ... 21.3 mmol) was acetylated as described for I0 by refluxing in dry toluene (90 mL) for 45 min ... dissolved in SOYO PEG 200-water, and were administered by the subcutaneous route in a final volume of 10 ...