The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine

PM O'Neill, AC Harrison, RC Storr…

Index: Journal of Medicinal Chemistry, , vol. 37, # 9 p. 1362 - 1370

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Citation Number: 67

Abstract

... 1366 Journal of Medicinal Chemistry, 1994, Vol. ... activity and toxicity by chemical modification is most striking for deOH-4'-FAQ (7), which does not undergo bioactivation to a reactive metabolite in uiuo but has similar antimalarial activity to amodiaquine and is, therefore, a ...