Chemistry of Heterocyclic Compounds

Antitumor antibiotics: duocarmycins

S Nagamura, H Saito

Index: Nagamura, Satoru; Saito, Hiromitsu Chemistry of Heterocyclic Compounds, 1998 , vol. 34, # 12 p. 1386 - 1405

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Citation Number: 7

Abstract

In our continuing search for biologically active compounds from microorganisms to develop new alkylating agents and other compounds that interfere with the functioning of DNA, novel potent antitumor antibiotics designated duocarmycins were isolated from three different Streptomyces species. The producing organisms of duocarmycin A (1) [1-5], that of duocarmycin B1 (2) [6], B2 (3) [7], C1 (4) [8], and C2 (5) [9, 10], and that of duocarmycin SA (6) [11, 12] were ...