Morita–Baylis–Hillman approach toward formal total synthesis of Tamiflu and total synthesis of gabaculine
S Bhowmik, S Batra
Index: Bhowmik, Subhendu; Batra, Sanjay European Journal of Organic Chemistry, 2013 , # 31 p. 7145 - 7151
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Citation Number: 5
Abstract
Abstract A Morita–Baylis–Hillman reaction mediated approach to the formal total synthesis of oseltamivir and the total synthesis of gabaculine is described. This strategy involves the enantiocontrolled preparation of Corey's intermediate in 22% yield, which is prepared over 11 steps starting from N-tert-butoxycarbonyl-L-serine methyl ester.
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