Regioselective preparation of 5-hydroxypropranolol and 4′-hydroxydiclofenac with a fungal peroxygenase

M Kinne, M Poraj-Kobielska, E Aranda, R Ullrich…

Index: Kinne, Matthias; Poraj-Kobielska, Marzena; Aranda, Elisabet; Ullrich, Rene; Hammel, Kenneth E.; Scheibner, Katrin; Hofrichter, Martin Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3085 - 3087

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Citation Number: 30

Abstract

An extracellular peroxygenase of Agrocybe aegerita catalyzed the H2O2-dependent hydroxylation of the multi-function beta-adrenergic blocker propranolol (1-naphthalen-1- yloxy-3-(propan-2-ylamino) propan-2-ol) and the non-steroidal anti-inflammatory drug diclofenac (2-[2-[(2, 6-dichlorophenyl) amino] phenyl] acetic acid) to give the human drug metabolites 5-hydroxypropranolol (5-OHP) and 4′-hydroxydiclofenac (4′-OHD). The ...