A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors

K Swierczek, AS Pandey, JW Peters…

Index: Swierczek, Krzysztof; Pandey, Arti S.; Peters, John W.; Hengge, Alvan C. Journal of Medicinal Chemistry, 2003 , vol. 46, # 17 p. 3703 - 3708

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Citation Number: 28

Abstract

Phosphorothioates, analogues of phosphate esters in which a sulfur replaces an oxygen atom in the phosphoryl group, are competent surrogate substrates for a number of phosphatases. In some cases the thio analogues show similar binding (as estimated by K m) while other phosphatases show quite different K m values for phosphate compared to phosphorothioate esters. On this basis it was hypothesized that there might be different ...