Ruthenium??Catalyzed Alkylation of Indoles with Tertiary Amines by Oxidation of a sp3 C H Bond and Lewis Acid Catalysis
MZ Wang, CY Zhou, MK Wong…
Index: Wang, Ming-Zhong; Zhou, Cong-Ying; Wong, Man-Kin; Che, Chi-Ming Chemistry - A European Journal, 2010 , vol. 16, # 19 p. 5723 - 5735
Full Text: HTML
Citation Number: 84
Abstract
Abstract Ruthenium porphyrins (particularly [Ru (2, 6-Cl 2 tpp) CO]; tpp= tetraphenylporphinato) and RuCl 3 can act as oxidation and/or Lewis acid catalysts for direct C-3 alkylation of indoles, giving the desired products in high yields (up to 82% based on 60– 95% substrate conversions). These ruthenium compounds catalyze oxidative coupling reactions of a wide variety of anilines and indoles bearing electron-withdrawing or ...
Related Articles:
On isotope effects for the cytochrome P-450 oxidation of substituted N, N-dimethylanilines
[Dinnocenzo; Karki; Jones Journal of the American Chemical Society, 1993 , vol. 115, # 16 p. 7111 - 7116]
Stereochemistry of β-deuterium isotope effects on amine basicity
[Perrin, Charles L.; Ohta, Brian K.; Kuperman, Joshua; Liberman, Jordan; Erdelyi, Mate Journal of the American Chemical Society, 2005 , vol. 127, # 26 p. 9641 - 9647]
The conformation of N-nitroso-N-methylaniline from microwave spectroscopy
[Caminati, W.; Giumanini, A. G. Journal of Molecular Structure, 1987 , vol. 162, p. 255 - 262]