Regioselectivity and mechanism of transpurination reactions in theguanine nucleosides series
J Boryski
Index: Boryski, Jerzy Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 3 p. 649 - 652
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Citation Number: 25
Abstract
The transpurination reaction of the fully acetylated derivatives of guanosine and its 7-β-D- ribofuranosyl regioisomer with 2-acetoxyethyl acetoxymethyl ether has been studied using high performance liquid chromatography (HPLC). The regioselectivity of glycosyl exchange observed in the early stages of the reaction suggests that the unsubstituted nitrogen atoms of the imidazole portion (N7 and N9) are, exclusively, sites of direct glycosylation in the ...
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