Tetrahedron

Synthesis of potential prodrug systems for reductive activation. Prodrugs for anti-angiogenic isoflavones and VEGF receptor tyrosine kinase inhibitory oxindoles

EA Blanche, L Maskell, MA Colucci, JL Whatmore…

Index: Blanche, Emilie A.; Maskell, Lesley; Colucci, Marie A.; Whatmore, Jacqueline L.; Moody, Christopher J. Tetrahedron, 2009 , vol. 65, # 25 p. 4894 - 4903

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Citation Number: 8

Abstract

A number of potential prodrug systems for reductive activation have been investigated. The prodrug systems chosen for the study were the 2-nitrophenylacetyl, 3-methyl-3-(3, 6- dimethyl-1, 4-benzoquinon-2-yl) butanoyl and 4-nitrobenzyl groups, readily attached to acidic OH or NH groups in drug molecules, and released upon bioreductive activation. The drug molecules studied were the naturally occurring isoflavone biochanin A, an inhibitor of ...