Fibrin-stabilizing factor inhibitors. 12. 5-Dibenzylaminopentylamine and related compounds, a new type of FSF [fibrin-stabilizing factor] inhibitors
KJ Hoffmann, P Stenberg, C Ljunggren…
Index: Hoffmann; Stenberg; Ljunggren; Svensson; Nilsson Journal of Medicinal Chemistry, 1975 , vol. 18, # 3 p. 278 - 284
Full Text: HTML
Citation Number: 14
Abstract
Method A. The appropriate secondary amine was alkylated using w-chloroalkylnitriles, usually 5-chlorovaleronitrile. The nitriles thus formed (compounds 14-26, 29, 33, 34, 36, 37, and 40, Table I) were then reduced to the corresponding primary amine using LiAlH4. This yielded the inhibitors 47, 48, 52-56, 61, 62, 64, 71, 73-75 and 77-80.
Related Articles:
Catalytic alkyl group exchange reaction of primary and secondary amines
[Murahashi; Yoshimura; Tsumiyama; Kojima Journal of the American Chemical Society, 1983 , vol. 105, # 15 p. 5002 - 5011]
[Bergeron, Raymond J.; Garlich, Joseph R.; Stolowich, Neal J. Journal of Organic Chemistry, 1984 , vol. 49, # 16 p. 2997 - 3001]
CsOH-promoted chemoselective mono-N-alkylation of diamines and polyamines
[Salvatore; Schmidt; Shin; Nagle; Worrell; Jung Tetrahedron Letters, 2000 , vol. 41, # 50 p. 9705 - 9708]
[Ishihara; Kato; Goto Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3225 - 3235]
Modular fluorescence sensors for saccharides
[Arimori, Susumu; Bell, Michael L.; Oh, Chan S.; Frimat, Karine A.; James, Tony D. Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 6 p. 803 - 808]