Synthesis and Anticonvulsant Activity of New N??Mannich Bases Derived from 5??Cyclopropyl??5??phenyl??hydantoins

…, J Obniska, A Czopek, K Kamiński

Index: Byrtus, Hanna; Obniska, Jolanta; Czopek, Anna; Kaminski Archiv der Pharmazie, 2011 , vol. 344, # 4 p. 231 - 241

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Citation Number: 10

Abstract

Abstract Synthesis, physicochemical and anticonvulsant properties of new N-Mannich bases 3–24 derived from 5-cyclopropyl-5-phenyl-and 5-cyclopropyl-5-(4-chlorophenyl)-hydantoins were described here. Initial anticonvulsant screening was performed using intraperitoneal (ip) maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizures tests. Selected derivatives were also screened in the 6-Hz test. The neurotoxicity was ...