Design, synthesis and biological evaluation of new classes of thieno [3, 2-d] pyrimidinone and thieno [1, 2, 3] triazine as inhibitor of vascular endothelial growth factor …

E Perspicace, V Jouan-Hureaux, R Ragno…

Index: Perspicace, Enrico; Jouan-Hureaux, Valerie; Ragno, Rino; Ballante, Flavio; Sartini, Stefania; La Motta, Concettina; Da Settimo, Federico; Chen, Binbin; Kirsch, Gilbert; Schneider, Serge; Faivre, Beatrice; Hesse, Stephanie European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 765 - 781

Full Text: HTML

Citation Number: 24

Abstract

Driven by a multidisciplinary approach combination (Structure-Based (SB) Three- Dimensional Quantitative Structure–Activity Relationships (3-D QSAR), molecular modeling, organic chemistry and various biological evaluations) here is reported the disclosure of new thienopyrimidines 1–3 as inhibitors of KDR activity and human umbilical vein endothelial cell (HUVEC) proliferation. More specifically, compound 2f represents a new lead ...

Related Articles:

Novel and Simple Methodology for the Synthesis of 3-Acetylindoles and their N-Alkyl Derivatives Using TBAB as Phase Transfer Catalyst

[Venkatanarayana; Dubey, Pramod K. Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 656 - 662]

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1, 3 (2 H, 4 H)-diones as dual inhibitors of human immunodeficiency virus type 1 …

[Barreca, Maria Letizia; Ferro, Stefania; Rao, Angela; De Luca, Laura; Zappala, Maria; Monforte, Anna-Maria; Debyser, Zeger; Witvrouw, Myriam; Chimirri, Alba Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 7084 - 7088]

Novel and Simple Methodology for the Synthesis of 3-Acetylindoles and their N-Alkyl Derivatives Using TBAB as Phase Transfer Catalyst

[Venkatanarayana; Dubey, Pramod K. Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 656 - 662]

Novel methods for the synthesis of functionalized indoles from arylhydroxylamines and activated acetylenes

[Hwu, Jih Ru; Patel, Himatkumar V.; Lin, Ren Jye; Gray, Marissa O. Journal of Organic Chemistry, 1994 , vol. 59, # 6 p. 1577 - 1582]

More Articles...