Synthése directe de β-hydroxyacides par réaction de Réformatsky

M Bellassoued, R Couffignal, M Gaudemar

Index: Bellassoued,M. et al. Journal of Organometallic Chemistry, 1973 , vol. 61, p. 9 - 18

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Citation Number: 13

Abstract

Abstract In tetrahydrofuran, the condensation of aldehydes and ketones with different salts of α-bromo acids yields, after hydrolysis, the corresponding β-hydroxy acids. This reaction can be brought about in a single stage, according to the Reformatsky traditional method, or else in two stages: preliminary preparation of the organozinc, then condensation with carbonyl compounds.