1, 3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2

…, M Singer, M Steber, DM Ritchie, DC Argentieri

Index: Sui, Zhihua; Guan, Jihua; Ferro, Michael P.; McCoy, Kathy; Wachter, Michael P.; Murray, William V.; Singer, Monica; Steber, Michele; Ritchie, Dave M.; Argentieri, Dennis C. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 601 - 604

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Citation Number: 73

Abstract

Novel 1, 3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2. The 1, 3-diaryl substitution pattern of the pyrazole ring in 1 differentiates these compounds from most of the known selective COX-2 inhibitors that contain two aryl rings at the adjacent positions on a heterocyclic or a phenyl ring. Similarly, the two phenyl rings in 2 are also separated by three atoms. SAR of both phenyl ...