A polymeric drug for treatment of inflammatory bowel disease
JP Brown, GV McGarraugh, TM Parkinson…
Index: Brown, Joseph P.; McGarraugh, Geoff V.; Parkinson, Thomas M.; Wingard, Robert E.; Onderdonk, Andrew B. Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1300 - 1307
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Citation Number: 169
Abstract
Sulfasalazine (SASP) consists of salicylic acid azo linked at the 5-position to a pyridine- containing sulfonamide. This drug, currently used in inflammatory bowel disease treatment, is reductively cleaved by anaerobic bacteria in the lower bowel to 5-aminosalicylic acid (5- ASA) and sulfapyridine (SP). Recent reports indicate that 5-ASA is the active therapeutic moiety and that SP is responsible for a variety of adverse clinical side effects. Water- ...
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