Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N??Methyltransferase: ω??Piperidinoalkanamine Derivatives

S Grassmann, J Apelt, X Ligneau, HH Pertz…

Index: Grassmann, Sven; Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger Archiv der Pharmazie, 2004 , vol. 337, # 10 p. 533 - 545

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Citation Number: 12

Abstract

Abstract In an effort to design new hybrid compounds with dual properties, ie binding affinity at histamine H 3 receptors and inhibitory potency at the catabolic enzyme histamine N τ- methyltransferase (HMT), a novel series of 1-substituted piperidine derivatives was synthesized. This alicyclic heterocycle is structurally linked via aminoalkyl spacers of variable lengths to additional aromatic carbo-or hetero-cycles. These new hybrid drugs ...