The solid phase synthesis of peptides containing an arginine residue with an unprotected guanidine group
YA Rubina, ZD Bespalova, VN Bushuev
Index: Rubina; Bespalova; Bushuev Russian Journal of Bioorganic Chemistry, 2000 , vol. 26, # 4 p. 235 - 244
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Citation Number: 4
Abstract
Abstract A new variant of the solid phase synthesis of arginine-containing peptides was proposed. The conditions for the attachment to the Wang polymer of {ie235-1}-Fmoc- arginine containing a protonated guanidine group were found. We demonstrated that this attachment is accompanied by neither racemization nor the attachment of the second Arg residue. Side reactions involving the guanidine group of arginine were studied, and ...
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