Synthesis of dinitrophenyltetrapeptides as chromophoric substrates of endoproteinases

…, NY Sokolova, SV Rodin, MA Samartsev

Index: Kulikov, S. V.; Sokolova, N. Yu.; Rodin, S. V.; Samartsev, M. A. Chemistry of Natural Compounds, 1983 , vol. 19, # 4 p. 469 - 475 Khimiya Prirodnykh Soedinenii, 1983 , vol. 19, # 4 p. 499 - 504

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Abstract

Abstract The synthesis has been performed of ten tetrapeptides of the general formula Dnp- Gly-Gly-X-Arg-OH, where X= Val, Phe, Abu, Asp (OBu t), Asp, Met, D-Phe, Ser, Thr, or Trp. The synthesis was carried out with Dnp-Gly-Gly-ONp, activated esters of protected amino acids, and arginine with an unprotected carboxy group. The coefficients of molar extinction of the tetrapeptides at 660 nm are given. It has been shown that the peptides can be used ...