An efficient synthesis of N-methyl amino acids by way of intermediate 5-oxazolidinones

…, RTC Brownlee, AB Hughes, MM Sleebs

Index: Aurelio, Luigi; Box, John S.; Brownlee, Robert T. C.; Hughes, Andrew B.; Sleebs, Marianne M. Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2652 - 2667

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Citation Number: 96

Abstract

N-Methyl amino acids occur in many natural products. Experimental strategies are presented for a unified approach to the synthesis of N-methyl derivatives through 5- oxazolidinones of the 20 common l-amino acids. The amino acids with reactive side chains that required protecting groups or devoted syntheses for side chain construction for N- methylation to proceed included serine, threonine, tyrosine, cysteine, methionine, ...