2??Amino??2′??[18F] fluorobenzhydrols, intermediates for the synthesis of [2′??18F]??1, 4??benzodiazepine??2??ones

P Johnström, S Stone??Elander

Index: Johnstrom; Stone-Elander Journal of Labelled Compounds and Radiopharmaceuticals, 1994 , vol. 34, # 2 p. 135 - 145

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Citation Number: 5

Abstract

Abstract A method for synthesizing 18 F-labelled 2-amino-2′-fluorobenzhydrols under nocarrier-added conditions for use as radiolabelled intermediates in the synthesis of [2′-18 F]-1, 4-benzodiazepine-2-ones is presented. Anilinodichloroborane reagents were formed by the reaction of boron trichloride with 4-chloro-N-methylaniline, 6a, 4-nitro-N- methylaniline, 6b, 4-nitro-N-ethylaniline, 6c, and 4-chloro-N-(2, 2, 2-trifluoroethyl) aniline, ...