Trifluoroacetaldehyde: A useful industrial bulk material for the synthesis of trifluoromethylated amino compounds

H Mimura, K Kawada, T Yamashita, T Sakamoto…

Index: Mimura, Hideyuki; Kawada, Kosuke; Yamashita, Tetsuya; Sakamoto, Takeshi; Kikugawa, Yasuo Journal of Fluorine Chemistry, 2010 , vol. 131, # 4 p. 477 - 486

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Citation Number: 46

Abstract

The synthesis of various trifluoromethylated amino compounds was studied using trifluoroacetaldehyde, an industrial bulk material, as a starting compound. One general application of trifluoroacetaldehyde is the preparation of trifluoroethylamino derivatives via reductive amination reaction. This synthesis includes the formation of the corresponding N, O-acetal intermediates followed by their reduction using NaBH4 or 2-picoline borane ...