Molecules

Hantzsch Synthesis of 2, 6-Dimethyl-3, 5-dimethoxycarbonyl-4-(o-methoxyphenyl)-1, 4-dihydropyridine; a Novel Cyclisation Leading to an Unusual Formation …

M Filipan-Litvić, M Litvić, I Cepanec, V Vinković

Index: Filipan-Litvic, Mirela; Litvic, Mladen; Cepanec, Ivica; Vinkovic, Vladimir Molecules, 2007 , vol. 12, # 11 p. 2546 - 2558

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Citation Number: 19

Abstract

Abstract: Hantzsch condensation of two equivalents of methyl-3-aminocrotonate with (m-and p)-methoxybenzaldehyde afforded the expected products 2, 6-dimethyl-3, 5- dimethoxycarbonyl-4-(m-methoxyphenyl)-1, 4-dihydropyridine and 2, 6-dimethyl-3, 5- dimethoxycarbonyl-4-(p-methoxyphenyl)-1, 4-dihydropyridine, whereas o-methoxy- benzaldehyde produced mainly 1-amino-2-methoxycarbonyl-3, 5-bis (o-methoxy-phenyl)- ...

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